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318 A study reported that Melatonin inhibits angiogenesis by downregulating the HIF1/ROS/VEGF pathway in HUVECs, 319 while its pro-oxidant activity may also contribute to anticancer effects, highlighting a context-dependent mechanism that warrants further investigation

We next examined the p K a values of the five cysteines: C8, C23, C26, C79, and C83, as cysteine thiol deprotonation is a critical step for subsequent glutathionylation or oxidation by H 2 O 2 32